FAQ written by Dr. Pietro Sodani,Cure Thalassemia co-founder & Scientific coordinator
Bone Marrow Transplantation (BMT) for Thalassemia
BMT from matching sibling
Is there a cure for thalassemia major?
Yes,it is Bone Marrow Transplantation (BMT),the only definitive cure for Thalassemia,with no more need of blood transfusions (thalassemia free).
What is Bone Marrow Transplantation (BMT) from a matching sibling (allogeneic BMT)?
Bone marrow transplantation (BMT) is used to treat diseases once thought incurable. Since its first successful use in 1968,BMTs have been used to treat patients diagnosed with leukemia,aplastic anemia,thalassemia major,lymphomas such as Hodgkin’s disease,multiple myeloma,immune deficiency disorders and some solid tumors such as breast and ovarian cancer.
In a bone marrow transplant,the patient’s diseased bone marrow is destroyed and healthy marrow is infused into the patient’s blood-stream. In a successful transplant,the new bone marrow migrates to the cavities of the large bones,engrafts and begins producing normal blood cells.
If bone marrow from a donor is used,the transplant is called an “allogeneic”BMT;the new bone marrow infused into the patient must match the genetic makeup of the patient’s own marrow as much as possible. A blood test,called “HLA typing”,is needed to know if donor’s bone marrow matches the patient’s.
Who has invented the Bone Marrow Transplantation (BMT) for thalassemia??
Prof. Lucarelli,in the 1980’s in Italy;he is Cure Thalassemia scientific advisor.
Who has the greatest experience in the world in Bone Marrow Transplantation (BMT) for thalassemia?
BMT for Thalassemia has been successfully performed since 1980’s on more than 3,000 patients worldwide. Prof. Lucarelli (Cure Thalassemia scientific advisor) and his team did about 1.500 BMT’s (about 50% of all the BMTs done in the world) in the last 30 years;Dr. Pietro Sodani (Cure Thalassemia scientific coordinator) did about 400 of them.
On PubMed,a free database managed by the US National Library of Medicine and the National Institutes of Health accessing primarily the MEDLINE database of references and abstracts on life sciences and biomedical topics,there are 267 scientific papers co-authored by Prof. Lucarelli and 24 by Dr. Sodani.
What are the results of Bone Marrow Transplantation (BMT)?
The results have substantially improved over the last two decades,due in large part to improvements in preventive strategies,the effective control of transplant-related complications,and the development of new preparative regimens.
The youngest the patients,the better are the results. In low risk (class 1 and class 2) young children in good shape,the thalassemia free is 89%,rejection is 8% and the mortality is 3%.
In class 3 patients,the thalassemia-free is 85%,the rejection is 8% and the mortality is 6%.
Why should I choose Cure Thalassemia to do a BMT?
There are at least 18 good reasons. Read them here.
How can I talk to a patient who did a Bone Marrow Transplantation (BMT) for a thalassemia?
You can use our BMT testimonials program.
How can I have the free advice of Dr. Pietro Sodani on Bone Marrow Transplantation (BMT)?
Dr. Pietro Sodani (our co-founder and scientific coordinator) gives his free advice via email to patients from all over the world. Read more information in this page.
Are there risks,complications and infections after a Bone Marrow Transplantation(BMT)?
First of all,there is a mortality risk,which is significantly lower than some decades ago;it goes from 3% to 6%,depending on the class of risk of the patient,his health conditions and the age.
BMT may not be successful causing a rejection,because of disease recurrence or regimen-related toxicity.
Having said that,in about 30% of the BMTs there might be complications,side effects or infections,and they are managed successfully;they are less frequent than some years ago thanks to a more accurate diagnosis and a higher number of antibacterial. The probability depends on some variables,like the class of risk of the patient and the outcome of the transplant.
Regimen-related toxicity refers to side effects that patients may experience during the course of transplantation. These side effects include graft-vs-host disease (GvHD),bacterial infections,fungal infections,viral infections,gastrointestinal and hepatic complications,neurologic complications,pulmonary complications,and late effects after stem cell transplant.
Infection complications are one of the most serious side effects;in same rare cases there is the fungal infection aspergillus,and if it is not treated well,it could be dangerous.
Conditioning regimens that usually consist of high-dose chemotherapy,radiation therapy,or both,can cause mucositis. Late effects after BMT includes endocrine (gland) problems like hypothyroidism,adrenal insufficiency or growth hormone insufficiency.
Although improvements in conservative treatment have considerably improved the prognosis of thalassemia,disease- and treatment-related complications in these patients progress over time,causing severe morbidity and shortened life expectancy,especially when the patient is not young.
What book do you suggest to read to know more about BMT?
“Bone Marrow and Blood Stem Cell Transplants:A Guide for Patients and family members”,written by Susan K. Stewart,Executive Director of BMT InfoNet and a transplant survivor herself.
Do patient’s appearances completely change after transplant (excessive weight gain,hair growth due to steroids)? Are these changes permanent?
All the complications related to weight gain and changed appearance are not permanent,and they are exclusively visible during the time of the therapy with cortisone and immunosuppressive drugs.
The length of these complications is variable,and it could happen that a patient during a cortisone therapy could have permanent problems to bones,joints and head of femur,but it is very rare.
My child has beta thalassemia major,can he be cured?
He can be cured (no more transfusions) with Bone Marrow Transplant(BMT). The best potential donors for a BMT are brothers and sisters;we need to know if he has brothers or sisters and how old is him.
My baby doesn’t have a matching sibling. What can we do to cure him from thalassemia?
These are other options that you have:
a) you can find a donor in a bone marrow donor bank. It usually takes time (3-6 months) and money
b) sometimes the mother is a compatible donor
c) even if the mother is not compatible,she can be used as donor:
For options b) and c),we suggest to do for both parents (sometimes the father can be used as donor) a simple blood test called HLA typing.
If the BMT is done on children under the age of 2,are there short/term effects?
In very young patients,the possible side effects are the same of older patients.
Are there risks for the bone marrow donor?
Usually no,but the donor has to do an anesthesia,so there are the risks involved in this procedure.
In most cases the stem cells are taken from the bone marrow,but sometimes,especially if there is a second transplant for the same patient,they must be the peripheral ones,and there is the need of infusion of the grow-factor that in same very rare cases could cause severe complications.
What are some the most useful scientific papers on Bone Marrow Transplantation (BMT)?
Cold Spring Harb Perspect Med.:Hematopoietic stem cell transplantation in thalassemia and sickle cell anemia –Lucarelli G,Isgrò A,Sodani P,Gaziev J.
Blood Journal:How I treat thalassemia - Eliezer A. Rachmilewitz1 and Patricia J. Giardina
Pediatric Reports:T cell-depleted hla-haploidentical stem cell transplantation in thalassemia young patients –Sodani P,Isgrò A,Gaziev J,Paciaroni K,Marziali M,Simone MD,Roveda A,De Angelis G,Gallucci C,Torelli F,Isacchi G,Zinno F,Landi F,Adorno G,Lanti A,Testi M,Andreani M,Lucarelli G.
Blood Journal:HLA-matched sibling bone marrow transplantation for β-thalassemia major - Mitchell Sabloff,Mammen Chandy,Zhiwei Wang,Brent R. Logan,Ardeshir Ghavamzadeh,Chi-Kong Li,Syed Mohammad Irfan,Christopher N. Bredeson,Morton J. Cowan,Robert Peter Gale,Gregory A. Hale,John Horan,Suradej Hongeng,Mary Eapen,and Mark C. Walters
NY Academy of science:Progress in hematopoietic stem cell transplantationas allogeneic cellular gene therapy in thalassemia - Antonella Isgrò,Javid Gaziev,Pietro Sodani,Guido Lucarelli.
Blood Journal:Purified T-depleted,CD34+ peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia - Pietro Sodani,Antonella Isgrò,Javid Gaziev,Paola Polchi,Katia Paciaroni,Marco Marziali,Maria Domenica Simone,Andrea Roveda,Aldo Montuoro,Cecilia Alfieri,Gioia De Angelis,Cristiano Gallucci,Buket Erer,Giancarlo Isacchi,Francesco Zinno,Gaspare Adorno,Alessandro Lanti,Lawrence Faulkner,Manuela Testi,Marco Andreani,and Guido Lucarelli.
Haematologica:Allogeneic stem cell transplantation for thalassemia major -Emanuele Angelucci and Donatella Baronciani
Blood reviews: Advances in the allogeneic transplantation for thalassemia - Guido Lucarelli,Javid Gaziev
NY Academy of science:Unrelated bone marrow transplantation for beta-thalassemia patients:The experience of the Italian Bone Marrow Transplant Group - La Nasa G,Argiolu F,Giardini C,Pession A,Fagioli F,Caocci G,Vacca A,De Stefano P,Piras E,Ledda A,Piroddi A,Littera R,Nesci S,Locatelli F.
Blood Journal:New approach for bone marrow transplantation in patients with class 3 thalassemia aged younger than 17 years –Pietro Sodani,David Gaziev,Paola Polchi,Buket Erer,Claudio Giardini,Emanuele Angelucci,Donatella Baronciani,Marco Andreani,Marisa Manna,Sonia Nesci,Barbarella Lucarelli,Reginald A. Clift,and Guido Lucarelli
Blood Journal:Bone Marrow Transplantation in Adult Thalassemic Patients –G. Lucarelli,R.A. Clift,M. Galimberti,E. Angelucci,C. Giardini,D. Baronciani,P. Polchi,M. Andreani,D. Gaziev,B. Erer,A. Ciaroni,F. D’Adamo,F. Albertini,and P. Muretto
What are the different classifications of patients of the Lucarelli protocol for BMT?
Prof. Lucarelli classifies the patients in 3 classes on the basis of presence of the risk factors hepatomegaly (enlarged liver),liver fibrosis and iron chelation history. Each class has different probability of cure.
Lucarelli Staging System for BMT:
Absence of hepatomegaly (enlargeed liver),regular iron chelation before transplant,absence of fibrosis in pretransplant liver biopsy result.
Hepatomegaly,a history of irregular iron chelation before transplant,histological evidence of liver fibrosis,or various combinations of the above.
All of the following:large liver,poor compliance with chelation therapy,liver damage
Class 2 or 3,irregular iron chelation,with a range of clinical symptoms and other diagnoses.
How do I understand the class of a patient?
1) to know when the patient has started the blood transfusions and the iron chelation
2) a liver biopsy or the more recently applied noninvasive T2* magnetic resonance imaging (MRI)
3) a liver ultrasound.
How many different Lucarelli protocols exist,and for which class of patients are they used?
In the last 30 years,Prof. Lucarelli has developed 3 different protocols,each one with a different drug regimen:
a) 6 for class 1 and 2
b) 6.1 for class 1 and 2 if the patient is less than 3 years old
c) 26 for class 3.
What is the minimum age for a BMT?
Thalassemic patients with an HLA identical donor should be transplanted as soon as possible.
Did Prof. Lucarelli and Dr. Sodani have performed BMTs on very young children i.e. between the age of 13 months –24 months?
Yes,and the the younger the patient,the better are the results.
How old a thalassemia major patient can be to be successfully cured with a BMT?
Thalassemic patients with a HLA identical donor has be transplanted as soon as possible,but the results in adult patients( age >17 years old) are not so brilliant.
Adult thalassemia patients are higher risk patients for transplant-related toxicity due to an advanced phase of disease and have a cure rate of 62% with current treatment protocol.
BMT is not the best therapeutic option for adult patients.
How do I know if I have a compatible donor?
You need to perform an HLA typing testing.
What is the probability to find an HLA-matched sibling donor?
Approximately 25% of thalassemic patients could have a sibling donor whose bone marrow is a perfect match.
What is the minimum age for bone marrow donor?
After 1 year of age.
What has to be done to know if a thalassemia patient can have a Bone Marrow Transplantation (BMT) from an HLA matching identical donor?
1) We need to know:
- the age of the patient
- if he has brothers and sisters
- when he started the blood transfusions
- the history of the iron chelation
- the most recent checked iron concentration
- if he is Hepatitis C Virus (HCV) positive
- the class of risk.
2) We need to know if there is an HLA matching identical donor in the family (father,mother,brothers and sisters). If not,we have to explore the possibility to open the bank research,but should be very expensive.
3) If there isn’t an HLA identical donor in the family and also from the bank,the mismatched haploidentical BMT from mother could be done.
If the donor is thalassemia minor/trait carrier,he can be used to do the Bone Marrow Transplantation(BMT)?
Yes,the donor with thalassemia trait could be an excellent donor.
If the donor has thalassemia intermedia,he can be used to do the Bone Marrow Transplantation(BMT)?
How do you collect the bone marrow from the donor?
It is collected under general anesthesia from the upper part of hip bone. It is done in day hospital.
When is there a perfect HLA match (identical donor)?
It is called 6/6 match,both from a related/familiar donor or from an unrelated.
Can the mother be an identical donor?
Yes,the mother can be 100% phenotypically identical if she shares one haplotype with her husband. In this case the patient can have a BMT using the mother ad the identical donor,and there is a higher risk of graft-vs-host disease (GvHD).
If the result of the HLA typing is 5/6,can the donor be used for the BMT?
It could be used,but we have the study the results of the HLA typing,because there might the risk of graft-versus-host disease (GVHD) and can be life-threatening.
This applies both for a related/familiar donor and for the unrelated.
Which is the minimum result of the HLA typing to know if the match is good enough so that the donor be used for the BMT?
The minimum is 5/6,with 4/6 or less it can’t be done.
What happens if the donor’s bone marrow is not a perfect (6/6) genetic match?
It could perceive the patient’s body as foreign material to be attacked and destroyed. This condition is known as graft-versus-host disease (GVHD) and can be life-threatening.
My son is thalassemia major and I have done his HLA Typing and there is a 4/6 match with the father and unfortunately we are unable to get 6/6 match
He could do the haploidentical BMT from the mother,or alternatively from the father.
May I know more about the Thalassemia major BMT process?
A patient admitted to the bone marrow transplant unit will first undergo several days of chemotherapy and/or radiation which destroys bone marrow and cancerous cells and makes room for the new bone marrow. This is called the conditioning or preparative regimen
Prior to conditioning,a small flexible tube called a catheter (sometimes called a “Hickman®”or central venous line) will be inserted into a large vein in the patient’s chest just above the heart.
A day or two following the chemotherapy and/or radiation treatment,the transplant will occur. The bone marrow is infused into the patient intravenously in much the same way that any blood product is given.
The transplant is not a surgical procedure. It takes place in the patient’s room,not an operating room. Multiple antibiotics and blood transfusions will be administered to the patient to help prevent and fight infection.
Transfusions of platelets will be given to prevent bleeding. There also medication medications to prevent and control graft-versus-host disease.
Once the BMT is done,how long does it take to stop doing the blood transfusions?
In most cases it happens within a month from the transplant. We anyway suggests to do a regular checkup for the first year,because there might be some complications related to the BMT,and also late rejections.
Once the BMT is done,do I still have to remove the excess iron,even if I don’t need anymore the blood transfusions?
Most patients keep doing iron chelation for 1 year and a half after the transplant,with a procedure called phlebotomy (salasso-teraphy).
If I do an HLA match test in one place,do I have to repeat it in the hospital where the BMT is done?
Yes,it is a best practice that the hospital doing the BMT repeats again the HLA match test,to be absolutely sure that the donor matches.
If I’ll have another baby he might have thalassemia major?
The probability that the new born will have thalassemia major is always 25%.
What is a BMT rejection?
The patient’s immune system may destroy the new bone marrow. This is called graft rejection.
If everything goes smooth and the BMT is successful,the patient will lead a normal life?
Yes,especially if the BMT is done as soon as possible.
If I don’t have an HLA-matched compatible donor,is it possible to do the BMT using the patient himself as the donor?
No,autologous Bone Marrow Transplant it is not an option to cure thalassemia.
What are the tests required to be done for a BMT,once that the donor has been found?
Abdominal Ultrasound,Chest X-rays and other ones that the doctor will ask,after having evaluated the the situation of the patient.
Is it necessary for the patient to keep particular food diet if he plans to do a BMT?
Food is not an issue,the patient can eat every kind of food.
What are the tests required for the donor?
An abdominal Ultrasound and the following blood tests:hematological clinical exam,endocrinological test and autoimmunity disease.
How long the patient doing the Bone Marrow Transplantation(BMT) has to stay in the hospital?
Usually 40-45 days.
How long the patient will have to stay close to the hospital doing the BMT,if he doesn’t live in the same city?
Generally 3 to 7 months.
Once that the patient has done the BMT and has left the hospital,for how long does he have to regularly come back for a weekly checkup?
There is a 3-6 month follow up with a weekly checkup done at the BMT center;it is delivered as a day hospital service,so the patient doesn’t have to live and sleep in the hospital.
My daughter has thalassemia major and she has an HLA identical sibling. Should we do the BMT as soon as her ferritin level is reaching the threshold where she would need to start the iron chelation therapy?
The BMT should be done as soon as possible,without waiting the need to start the iron chelation therapy.
My daughter has Haemoglobin E-Beta thalassaemia. Can she do a BMT?
Yes,but only if she is transfusion-dependent and she is having regular blood transfusions.
My son has thalassaemia lepore. Can he be cured with BMT?
Yes,but only if he is transfusion-dependent and he is having regular blood transfusions.
I would like to get your opinion on reduced-intensity BMT. Between the traditional and the reduced,which procedure do you feel would be best for my son?
We don’t believe in reduced-intensity transplant,especially for very young children.
What is better,a BMT from a HLA-matched sibling at a later age or Haploidentical Mother BMT at the earliest age possible?
It is always better to do a BMT from an HLA-matched sibling,there are higher results and less risks.
What is the difference between a related/familiar and an unrelated donor?
A related donor is a family member of the patient (mother,father,brothers and sisters);an unrelated is anybody else,and it usually can be found in bone marrow donor banks.
What is a “non identical” donor?
It means that result of the HLA typing is less than 6/6 (which is the identical matched donor),so 5/6 or less. It is also called mismatched.
If the patient doesn’t have an HLA matching sibling,can we do a search of an unrelated bone marrow donor from a bank?
You can try,but the probability to find matched unrelated donor is low,especially if the bone marrow bank has few donors with the same ethnic background of the patient.
How much does it cost to do a research of an unrelated bone marrow donor from a bank?
From 10,000 USD up to 400,000 USD,depending on how many searches are done,how many donors have a good match,and some other variables.
How long does it take to do a research of an unrelated bone marrow donor from a bank?
On average 6 months.
If I find an unrelated identical donor in a bank,will the donor certainly donate?
Usually yes;but in some rare cases it could happen that donor doesn’t want to donate anymore,or he is not in good health conditions.
If I don’t have an HLA-matched sibling,it is better to use an unrelated donor (from a bank),or the mother?
It is better the unrelated donor only if the patient is class1 or class2,and if the HLA match of the donor is 6/6.
In all other cases (HLA match of 5/6 or lower;every class3 patient),it is better to use the mother (haploidentical BMT);anyway,if the donor has the same HLA typing of the mother,he can be used,especially if the mother is not available.
It is better to use as donor an HLA-matched sibling (brother or sister),or an unrelated donor from a bank?
For class 1 and class 2 patients,if the HLA match is 6/6 both for the matched sibling and for the unrelated donor,the results of the BMT are the same;for class 3 we use the sibling.
If it is 5/6 for both,we use the sibling.
If the sibling is 5/6 and the unrelated donor is 6/6,we use the unrelated donor.
My son has thalassemia major,we have a 4/6 match from the father but unfortunately we didn’t find any 6/6 match. What we should do?
In this case it is better to use the mother (haploidentical BMT) as the donor;if for any reason the mother can’t be used,then the father is the second best option.
My son doesn’t have an HLA-matched sibling,and I’ve found maximum a 5/6 match in the unrelated donors bank. We want to go for another baby only as last option,what are the risks and the chances?
If you’ll have another baby,there is a 25% probability that he will have thalassemia major as well. Having said that,there is a 25% probability that he will be a 6/6 HLA match. You can also consider to have haploidentical BMT from the mother.
I have recently adopted a child who has been found to have a certain form of thalassemia. We have been called today to start transfusions and would like to understand if we can have a chance to receive BMT considering that our child is adopted and we do not know who and where they parents and/or relatives live.
First of all we need to know exactly what kind of thalassemia is. If there is no way to get in touch with the parents,brothers and sisters,you can try to search an unrelated matching donor through a donor registry bank. The search can only be done through an hospital.
Can I plan to have 1 more baby and use the umbilical cord blood for the BMT?
In case of HLA compatibility of a matching sibling,we prefer to use the bone marrow and not the cord blood,because with the cord blood there is a higher risk both of rejection and to have a graft-versus-host disease (GVHD).
During our daughter’s birth I had preserved her stems cells of the umbilical cord. Can they be used for a BMT?
No,because the patient can’t be a donor (autologous BMT),nor with his umbilical cord and nor with his bone marrow.
My son is thalassemia major,and his brother umbilical cord blood is stored at the time of the birth. Is it possible to use it?
You have to tell us where the umbilical cord is stored and you have to inform the hospital doctor team that you want to perform the HLA of umbilical blood to test the grade of antigen disparity. In other words we have to know if the cord blood is HLA identical or not.
My child is thalassemia major and he doesn’t have a matching sibling,can we use the mismatched unrelated cord blood?
The use of mismatched,unrelated cord blood is still experimental.
How easy it is to find a mismatched unrelated donor for cord blood transplant?
It is impossible to predict the probability to find a cord blood identical from the bank. Many factors are involved,so there isn’t an easy answer,but,from our experience,the possibility is low.
If a thalassemia patient is Hepatitis C Virus (HCV) positive,can he receive Bone Marrow Transplantation(BMT)?
If there is an HLA-matched identical donor we can do the BMT for a patient who is HCV positive.
HCV is not an issue,we just have to be more careful to prevent infections.
If the donor is Hepatitis C Virus (HCV) positive,can we do anyway the Bone Marrow Transplantation(BMT)?
No,if the donor is HCV positive,his bone marrow can’t be used.
Is there a replacement for blood transfusions? I have not been feeling well lately after my blood transfusion. Is there anything I can do?
Unfortunately,you must keep doing do iron chelation therapy and transfusions. The only way to stop doing transfusions is a Bone Marrow Transplantation (BMT).
I have a child with alpha thalassemia and I want to know if he could receive BMT
There is no experience in BMT in alpha thalassemia.
I’ve given you all the information about my son,who has thalassemia major. Do you suggest to do the BMT?
From an ethical point of view he can’t tell you what to do. As doctors,our role is to tell you the facts and the risks,but the final decision must be taken by you.
BMT from haploidentical mother to child with thalassemia
If I don’t have an HLA-matched compatible donor,can the BMT be done using the mother (haploidentical BMT)?
There is another recent cure called BMT from haploidentical mother (mismatch donor),in which usually the donor is the mother or in some cases the father. It has been invented by Dr. Pietro Sodani and published on Blood journal on November 2009:
Purified T-depleted,CD34+ peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia.
There is also a more recent update on Pediatric Reports in June 2011:
T cell-depleted hla-haploidentical stem cell transplantation in thalassemia young patients.
The mother is at least 50% identical,and the fetus inherited half from mother,half from father.
Haploidentical BMT has been explored as an option for treating patients with leukemia who lack an HLA-identical sibling or parent donor. Feto-maternal microchimerism suggests immunological tolerance between mother and fetus. Thus,we performed a BMT from mismatched mother to thalassemic patient without an HLA-identical donor.
If the patient doesn’t have an HLA identical donor from family and also from the bank,the mismatched transplant from mother could be a therapeutic strategy.
What are the results of the Haploidentical Mother BMT?
Thalassemia free is 67%,rejection 23% and mortality 10%. The best results are with very young patients.
When the first Haploidentical Mother BMT was done?
In 2002,by Prof. Lucarelli and Dr. Sodani.
How many Haploidentical Mother BMT have been done?
About 45,of whom 22 have been published on Blood Journal in November 2009.
Where the Haploidentical Mother BMT is done?
It is done in Rome,Italy at IME,where Prof. Lucarelli and Dr. Sodani works. In the near future we plan to do it at Narayana Hrudayalaya in India,under the scientific supervision of Prof. Lucarelli and Dr. Sodani.
What is the protocol for the Haploidentical Mother BMT?
It is protocol 30,developed by Dr. Pietro Sodani and Prof. Lucarelli.
What is the minimum age for an Haploidentical Mother BMT?
What is the price of a Haploidentical Mother BMT?
In Italy it is about 200,000 USD. We plan to do it in India at a significant lower price.
Can we do BMT with parent as donor even in case of mismatch?
Yes,because the mother and the father are often mismatch with the patient,and they can be used as donor in the Haploidentical BMT.
Can the mother be a donor if she is also thalassemic carrier/trait?
Yes,the mother of thalassemic child is by definition a carrier/trait,and she can be used as donor in the haploidentical BMT.
My daughter has Thal Major.I want to know whether either of my husband or myself could be successful bone marrow donors for our daughter considering we’re second cousins (our dads are first cousins)?
Yes,you can be donors even if you are “second cousins”.
Cure Thalassemia-Narayana Hrudayalaya/Mazumdar Shaw Cancer Centre
Where can I read more?
We have a page dedicated to this topic
Do you accept patients from all over the world?
Yes,we are glad to have thalassemia patients from all over the world.
What is a social business?
A Social Business (as defined by by the 7 principles of the Nobel Prize Yunus) is a non-loss,non-dividend company designed to address a social problem,and not to look for profit maximization. The investors cannot take any dividend;it is financially self-sustainable,without relying on donors’ money. People working in it are paid at market prices.
Who is Prof. Yunus?
He is the inventor of micro-credit,Grameen Bank and the social business concept. Nobel Prize winner in 2006. Rear more in his website.
Why Cure Thalassemia is a social business and not a charity or a “for profit” company?
Charity is hard to be financially self-sustainable you need a constant flow of donors money,and it is though to do Bone Marrow Transplantation (with 3 doctors,8 nurses and 2-3 other staff people) just rely on donors.
At Cure Thalassemia we believe that money is not the most important thing in like,and that’s why we have decide to follow the Social Business of Prof. Yunus,where investors don’t get any profit,and the goal of the company is to solve a social problem,in this case to cure thalassemia patients.